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Literature Summary

Major Literature

  1. Kress. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471-7
    • In a single centre, randomised, controlled trial comparing daily sedation hold with continuous sedation in 128 critically ill mechanically ventilated adults, sedation hold decreased the median durations of mechanical ventilation (4.9 days versus 7.3, p=0.004) and ICU length of stay (6.4 days versus 9.9 days, p = 0.02) as well as the requirement for diagnostic testing for changes in mental status (9% versus 27%, p = 0.02). There were no significant differences in adverse events, including self extubation (intervention group 4% versus control group 7 %, p = 0.88).
  2. RESTORE Study Investigators. JAMA. First published on line Jan 20 2015: doi10.1001/jama.2014.18399
    • The use of a sedation protocol compared with usual care did not reduce the duration of mechanical ventilation in critically ill children presenting with acute respiratory failure
  3. Mehta. Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol. A Randomized Controlled Trial (SLEAP study). JAMA 2012;308(19):1985-1992