Endotheliopathy

Definitions

Figure 1: The Coagulation Cascade


Pathophysiology

Hemolytic Uremic Syndrome (HUS)

Thrombotic Thrombocytopenic Purpura (TTP)

Disemminated Intravsacular Coagulation (DIC)

Thrombocytopenia Associated Multiple Organ Failure (TAMOF)

Sepsis

References

1) Nguyen TC, Han YY, Kiss JE, Hall MW, Hassett AC, Jaffe R, Orr RA, Janosky J,Carcillo JA. Intensive plasma exchange increases a disintegrin andmetalloprotease with thrombospondin motifs-13 activity and reverses organdysfunction in children with thrombocytopenia-associated multiple organ failure. Crit Care Med. 2008 Oct;36(10):2878-87.

2) Nguyen TC, Carcillo JA. Bench-to-bedside review: thrombocytopenia-associatedmultiple organ failure--a newly appreciated syndrome in the critically ill. Crit Care. 2006;10(6):235.

3) George JN, Nester CM. Syndromes of thrombotic microangiopathy. N Engl J Med.2014 Aug 14;371(7):654-66.

4)  Kawai Y, Cornell TT, Cooley EG, Beckman CN, Baldridge PK, Mottes TA, Luckritz KE, Plomaritas KS, Meade JM, Odetola FO, Han YY, Blatt NB, Annich GM. Therapeuticplasma exchange may improve hemodynamics and organ failure among children withsepsis-induced multiple organ dysfunction syndrome receiving extracorporeal life support. Pediatr Crit Care Med. 2015 May;16(4):366-74.

5) Sevketoglu E, Yildizdas D, Horoz OO, Kihtir HS, Kendirli T, Bayraktar S,Carcillo JA. Use of therapeutic plasma exchange in children withthrombocytopenia-associated multiple organ failure in the Turkishthrombocytopenia-associated multiple organ failure network. Pediatr Crit CareMed. 2014 Oct;15(8):e354-9.