Literature Summary

Major Literature

1. Finfer. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004;350(22):2247-56

2. Myburgh. Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care (CHEST study). NEJM 2012;367:1901-1911

3. Maitland. Mortality after Fluid Bolus in African Children with Severe Infection (FEAST Trial). N Engl J Med 2011;364:2483-2495   (Paediatric Study)

Albumin vs. Crystalloid:

Current Guidelines

2012 - Adult Surviving Sepsis Campaign

2012 - Pediatric Surviving Sepsis Campaign

So the guidelines are unclear when to use one over the other...

Recent Meta-analyses

2011 - The Role of Albumin as a Resuscitation Fluid for Pts with Sepsis (Critical Care Med)

2013 - Colloids vs. Crystalloids for Fluid Resuscitation in Critically Ill Pts (Cochrane Review)

Recent RCT Not Included in the Above Meta-analyses

2013 - Effects of FLuid Resuscitation with Colloids vs. Crystalloids in Hypovolemic Shock (JAMA)

Myburgh, NEJM 2013