Hyperleukocytosis and Leukostasis

Definition

From: Rollig et al, Blood 2016. Demonstrating evidence of pulmonary and CNS leukostasis


Pathophysiology

From Rollig et al, Blood 2016


High numbers of circulating blasts leads to sludging, obstruction of capillaries and subsequent tissue malperfusion. In addition, circulating blasts induce endothelial adhesion receptor expression (ie E selectin, P selectin ICAM-1) leading to further adhesion and sludging.  

Diganosis

Treatment